THE BEST SIDE OF PKRRATING

The activated enzyme then phosphorylates its key substrate, the translational initiation factor eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to the conserved family members of 4 protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in response to diverse stimuli12, triggering the built-in strai